Particle size control in vitamin C industrial production（2）

Particle size control in the preparation of vitamin C tablets:

In the preparation of vitamin C tablets, the quality of vitamin C tablets produced with different prescriptions varies. Therefore, in order to save costs during the production process and comply with national regulations, it is necessary to conduct quality inspections on semi-finished products and finished products with different prescriptions. Comparisons were made through several aspects such as particle fluidity, particle size distribution, particle hygroscopicity, tablet disintegration, hardness and friability.

In the quality inspection of semi-finished and finished products of vitamin C tablets, the particle size distribution measurement method is: use an industrial sieve with apertures of 960 μm (20 mesh), 450 μm (40 mesh), and 300 μm (60 mesh) to analyze the particle distribution, and take the average of three times value. Place 100g of particles on the top layer of the standard sieve, place it on the oscillator and oscillate at 800r/min for 5 minutes. Distribute the particles above 9600 μm, 960-450 μm and below 300 μm and weigh them. Calculate the percentage of particles of different sizes.

According to which prescription has more large particles with a particle size distribution range greater than 960 μm, and which prescription has more small particles less than 300 μm. What percentage of different prescriptions account for medium particles between 300-960 μm can be used to determine what kind of prescription is both cost-saving and highly effective, and can also determine whether it can meet tableting needs.

It can be seen that in the preparation of vitamin C tablets, particle size detection has become an important consideration standard for its finished and semi-finished products, and laser particle size detection has gradually become the most important detection method in the vitamin C production industry.

Application of laser particle size analyzer in vc industry

Shandong Luwei Pharmaceutical Co., Ltd. is located in Shuangfeng Industrial Park, Zichuan District, Zibo City. It is one of the five largest vitamin C manufacturers in China. The company has a well-equipped VC inspection center, engineering and technical personnel, advanced equipment and well-functioning supporting facilities. It always regards rigorous production technology and excellent product quality as the basis for survival and development. It has passed the pharmaceutical GMP certification and ISO9001 international quality system. Certification, ISO22000 food safety management system certification, ISO14000 environmental management system certification, ISO18000 occupational health and safety system certification, safety standardization level three certification, IP non-GMO identity maintenance product certification, FAMI-QS European feed additives and premixed feed quality system certification, KOSHER, HALAL international religious kosher certification, the first in the city to pass the clean production certification, and was recognized as a "high-tech enterprise" by Shandong Province. In order to maintain continuous technological innovation capabilities, the Zibo Vitamin C Engineering Technology Research Center was established to gather scientific research forces, strengthen product research and development, and promote technological research.

Due to the needs of R&D and production of VC products, Shandong Luwei Pharmaceutical Co., Ltd. cooperated with Jinan Micro-Nano Particle Instrument Co., Ltd. to use winner3003 for product particle size testing. Through product testing and analysis, we provide technical basis for quality inspection and optimization.

https://www.winner-psa.com/micron-particle-size-analyzer/winner-3003-dry-dispersion-laser-particle-size-analyzer.html