Application of laser particle size analyzer in florfenicol

Florfenicol, also known as flufenicol, is an animal-specific broad-spectrum chloramphenicol developed by the American Schering-Plough company in the late 1970s. Antibiotic, its chemical name is D(ten)-threo-1-p-methylsulfonylphenyl-2-dichloroacetamido-3fluoropropanol. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safe and efficient, and not easy to develop drug resistance. It has a remarkable therapeutic effect on bacterial diseases of livestock and poultry caused by sensitive bacteria. The drug was first launched in Japan in 1990 and is mainly used in the aquaculture industry. It has been registered in Japan, Norway, France, the United Kingdom, Austria, Mexico, Spain and other countries. It was approved for marketing in China in April 1999 and was approved by the Ministry of Agriculture as a Class II new veterinary drug. It is mainly used to treat infections caused by sensitive bacteria. For bacterial diseases of pigs, cattle, chickens and fish, the dosage forms produced include water injections, solutions and powders. Nanoemulsion is also called microemulsion.The particle size is generally 1 to 100 nm. It is a stable, transparent, low-viscosity emulsion formed by oil phase, water phase, surfactant and co-surfactant in appropriate proportions. As long as the composition of the four phases is appropriate, a uniform, transparent or slightly opalescent liquid can be formed, which is a thermodynamically stable system [40]. Nanoemulsion has the following advantages: good physical stability, which can greatly improve the stability of drugs and the solubility of poorly soluble drugs in water; small and uniform particle size, which can improve the dispersion of drugs and promote drug absorption in the body; It can improve the bioavailability of drugs; the preparation process is simple and easy to preserve.

It can be seen that the particle size of florfenicol has a profound impact on its effect. This time Winner3003 is recommended to test florfenicol samples for customers.

Measuring instrument information is as follows:

The video of measuring nanoparticles is as follows：