Application of nanoparticle size analyzer in breast implants

Vaccine testing is mainly divided into microbiological testing, such as using culture methods to detect whether bacteria, mycoplasma and other microorganisms are contaminated, using tissue culture and electron microscopy to detect whether viruses are contaminated, and using pure bacterial experiments to detect viable bacteria, total bacterial count and other hybrids. For the presence of bacteria, immunological tests are used to identify the immune properties of the vaccine and standardize the vaccine. Physical and chemical property testing, such as protein measurement, nucleic acid measurement, polysaccharide spectrum measurement, particle size, ζ potential, stability, etc. Stability is closely related to particle size. For example, the agglomeration of milk particles in milk powder is a common phenomenon during comparative analysis during the formulation technology development and design process. Let’s take a look at the application of nanoparticle size analyzer on breast implants!

Oil-in-water emulsions are particularly suitable for adjuvant formulations of influenza virus vaccines. These lactose compounds that have been marketed can usually contain at least one oil and at least one surfactant. The requirement is that one or more oils and one or more surfactants are biological materials. Degradable (metabolizable) and biocompatible. Microfluidic devices are often used to obtain oil droplets in emulsions in small sizes to obtain stable emulsions. Oil droplets smaller than 220 nm in size are preferred because we can perform information filter sterilization on them.

From the perspective of cellular phagocytosis, nanoparticles smaller than 1 μm are more likely to be phagocytosed by DCS and macrophages, and particles smaller than 1 μm are most suitable for triggering systemic immunity. From the perspective of particle transmission, nanoparticles with small particle sizes are easier to transmit data and continuously improve the effect of autoimmune treatment. However, if the particle size is too small, the nanoparticles will penetrate into the blood vessels, and if the particle size is too large, it will affect its transmission. Development speed. The corresponding nanoemulsion additives currently on the market and in the clinical research stage (such as MF59, AS01-04 series, NB001-002 series, etc.) generally have a particle size of 90-200nm.

 Dynamic light scattering is a research method commonly used to analyze particle size data of nanoparticle size analyzers for detecting breast cancer. The principle is to determine the size of particles by measuring their movement speed in a solvent, and the normal distribution is usually used to display the size distribution of particles. However, our nanoemulsions that are in the corporate research and development stage are usually due to the uncertainty of the production process or formula, and problems such as milk particle agglomeration often occur. At this time, only the Gaussian distribution can only be used to detect the average particle size distribution, which is mainly wide. The PI value becomes larger.

Gaussian distribution and Nicomp multimodal distribution complement each other and can distinguish the true particle size distribution of complex multi-component samples, helping researchers to accurately determine the true distribution of samples and particle size components. In addition, it can be combined with the single-particle optical sensing network technology of the AccuSizer series to provide information on the size of the large particles at the tail end and the number of companies. By analyzing the particle size one particle at a time, the differences in the samples can be visually distinguished, so that the formula design can be reversed or Production process, guide your own research and development.