On March 12-13, 2019, the National Pharmaceutical Powder Preparation and Physical Property Characterization Technology Summit Forum hosted by China Powder Network was grandly held in the beautiful spring city of Jinan. The purpose of this forum is to enhance pharmaceutical workers' understanding of powder science and learn the application of powder engineering in the pharmaceutical field.
The absorption rate of a drug in the human body is determined by the speed of dissolution. Solid preparations must undergo disintegration, dissolution, and finally conversion into a solution before absorption. If the dissolution rate of the drug is extremely slow or difficult to dissolve, the absorbability of the drug will be greatly reduced. . On the other hand, some drugs have too severe pharmacological effects and low safety index. If they are dissolved and absorbed too quickly in the human body, it may cause obvious adverse reactions in the patient and the maintenance time of the drug effect will also be shortened. Therefore, the dissolution rate of the drug must be controlled in this case. Particle size has a great influence on drug dissolution, and the control of the particle size of raw materials directly affects the absorption and efficacy of the drug. Most pharmaceutical powders are relatively soluble in water, so the dry method is generally used to test the particle size of pharmaceutical powders. Winner3000 series laser particle size analyzers or winner2308 and winner2309 wet and dry laser particle size analyzers are applicable. Winner customers include companies and research institutes in the pharmaceutical industry, such as Qingdao Guohai Biopharmaceutical, Shandong Academy of Medical Sciences, China Agricultural University, etc., all use the winner3000 series.
Medical sprays have developed rapidly in recent years. Their mechanism of action and low toxic and side effects have been favored by more and more people. Packaging containers, production equipment, processes and technologies have also been continuously improved, and the scope of applications and product types have continued to increase. As a non-injection delivery system for peptide and protein drugs, pharmaceutical sprays have attracted more and more attention from researchers and are currently widely used in the medical field. Aerosols, sprays and powder sprays are three dosage forms that are closely related but have huge differences. Aerosols are driven by propellants; powder atomizers rely on human breathing for power and are mainly inhaled; sprays are a unique dosage form that have the advantages and characteristics of atomized drug delivery and avoid the use of propellants, especially Used for administration on skin, mucous membranes, limb surfaces, cavities and other parts of the body. With the ban on aerosol propellant Freon in recent years, many aerosol products are also learning the process ideas of sprays, and sprays have developed rapidly.
The Win311XP spray laser particle size analyzer is a desktop spray laser particle size analyzer based on the principle of Mie scattering and developed to meet the particle size requirements of inhalation aerosols, sprays, powder sprays, etc. in the National Pharmacopoeia. It can analyze various small spray devices. The test integrates a variety of patented technologies of Winner Company. It has a compact appearance and can well test the particle size of small sprays and achieve rapid data collection. It can reliably and continuously measure the particle size distribution of atomized droplets in real time during the spray process. , the measurement can be completed within 60 seconds and a detailed data report is provided. It can effectively guide manufacturers to conduct finished product inspection and technological research and development, bringing profits and benefits to enterprises. In addition to pharmaceutical preparation companies such as Changzhou Siyao, Jiangsu Wanbang, and Chengdu Kanghong, the users of the 311xp spray particle size analyzer also have many research institutes, such as Shanghai Medical Device Testing Institute, Shaanxi Provincial Food and Drug Administration, Henan Medical Device Research Institute, etc. .
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